2-(4-tert-butyl-phenoxy) cyclohexanol was synthesized through the reaction of 4-tert-butylphenol with epoxycyclohexane in the presence of catalyst, and through two steps of thionyl chloride derivatives alcoholysis, neutralization to produce propargite under condition of 15 ℃. 1NMR and IR were performed to determine the structure of intermediates and final product. The results show that the analytical sample is identical to authentic, and the chemical structure and the quality of this compound agreed with those of imported samples. Factors influencing the reaction yield were studied, such as feeding mode and reactions times. The optimum technical condition: 2-(4-tert-butyl-phenoxy) cyclohexanol is prepared from 4-tert-butylphenol and epoxycyclohexane and then thionyl chloride derivatives alcoholysis chlorinated sulfoxides to get intermediates. Intermediates reacted with propargyl alcohol in the presence of toluene to obtain the target material of 2-(4-tert-butyl-phenoxy) cyclohexanol. The total yield can be reach to 82% (based on 4-tert-butyl-phenol) and the purity is 98%.